CD4/CD8 ratio and age related health outcomes in HIV infected patients.

Marianna Menozzi

Aging HIV-infected patients show increased risk of developing comorbidities. CD4/CD8 ratio inversion is associated to Non-Communicable Diseases and frailty.
We aim to describe associations between CD4/CD8 ratio and meaningful endpoints of aging with HIV (Multimorbidity – MM, Frailty – FI and Disability – D).

Cross sectional study. Inclusion criteria: HIV-infected adults, HIV-VL2 comorbidities. FI: Frailty Index >0.31. D: >=1 deficit at IADL or SPPB<9 or Falls.
After descriptive analysis according to CD4/CD8, logistic regression models sex and age-adjusted were used to assess relation between CD4/CD8 and MM, FI and D.

2945 patients included. CVD, HTN, DM, COPD, MM and FI were more prevalent in the low CD4/CD8 group (p<0.05). No differences found in D items prevalence.
At regression models a protective role of CD4/CD8 was confirmed regarding CVD, MM and FI (p<0.05). No association was found between CD4/CD8 and D.
At further models, higher CD4 nadir was positively associated with high CD4/CD8. Male sex, MM and FI had negative association.

A novelty of our study was the independent association between routinely performed markers of immune-reconstitution and features of aging HIV-infected patients: low CD4/CD8 association with comorbidities alone or aggregated in MM and FI. It was also confirmed the association between MM, FI and low CD4/CD8 ratio.

Simone Agnello
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