01 Set Frailty improves in both young and old HIV patients undergoing Atazanavir based regimens

Iacopo Franconi

Frailty is a measure of biological ageing able to depict changes in health status that include improvement, maintenance and deterioration and suitable to describe the benefit of antiretroviral regimens. The objective of this analysis was to describe Frailty Index change in HIV patients, undergoing effective Atazanavir (ATV) based regimens overtime. Data were collected from patients attending Modena HIV Metabolic Clinic Cohort Study, in a 4 year follow up period. We included 406 patients undergoing a stable and effective ATV based regimens: 262(64.53%) patients were undergoing boosted- ATV and 144(35.47%) unboosted-ATV regimens. HIV patients on stable ATV based regimen experienced improvement in health status depicted by a reduction in FI. A significant switch from frail to fit health status was function of Longer duration of HIV infection, baseline frailty index but not age or boosted vs unboosted ATV regimen.
This study underline the versatility of ATV based regimen in both younger and older HIV a patients with different spectrum of health profile.