Blood stream infections (BSI) complicate the neutropenic phase of HSCT. Knowledge of aetiology and antibiotic resistance is crucial to set up an effective antibiotic therapy and reduce mortality. Pre-engraftment (PE) BSI were studied retrospectively in 271 patients undergoing allogenic HSCT between 2013 and 2016. We investigated...
Gli anticorpi contro l’antigene core di HBV (anti-HBc) sono presenti nel 14-44% dei pazienti con infezione da HIV. Rimane una problematica dibattuta se la vaccinazione anti HBV debba essere consigliata ai pazienti HIV positivi con isolata positività per anti-HBc (IAHBC). Ci siamo proposti di indagare...
Il paziente anti-HIV positivo è ad alto rischio cardiovascolare. Il polimorfismo di un gene, il TM6SF2 nella variante E167E, è stato recentemente correlato con l’insorgenza di dislipidemia e dunque di patologie cardiovascolari e sviluppo di placche carotidee. Al fine di valutare l’inspessimento medio-intimale nei pazienti...
Natalizumab (NTZ) increases the risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus JC (JCV). The aim of the study was to describe the modifications of matrix metalloproteinase (MMP)-9 activity during NTZ treatment in parallel with T-lymphocyte phenotypic alterations. Thirty-nine relapsing remitting multiple...
Increased levels (lvs) of chemokine interferon-γ-inducible protein-10 (CXCL10), soluble (s) CD163 and sCD14 have been reported in HCV infection. The aim of this study was to compare biomarkers lvs in HCV-infected patients (pts) undergoing direct acting antiviral (DAA) regimens with or without interferon (IFN). sCD163, sCD14...