AIM We investigated the associations of statin use and exposure to antiretroviral drugs with type 2 DM onset in a cohort of HIV-infected patients. METHODS This retrospective, controlled, cohort study identified HIV-1-infected patients who did not have DM and were not receiving statins at their antiretroviral treatment (ART)...
Objectives: to investigate the association between total (TBIL), direct (DBIL) and indirect (IBIL) bilirubin and the presence of carotid lesions in a cohort of HIV-1 infected patients on virological suppression. Methods: cross-sectional study on adult HIV-1 infected patients with a carotid ultrasound (CUS) examination, with HIV-RNA...
Il paziente anti-HIV positivo è ad alto rischio cardiovascolare. Il polimorfismo di un gene, il TM6SF2 nella variante E167E, è stato recentemente correlato con l’insorgenza di dislipidemia e dunque di patologie cardiovascolari e sviluppo di placche carotidee. Al fine di valutare l’inspessimento medio-intimale nei pazienti...
L’infezione da HIV è caratterizzata da una precoce deplezione delle cellule T CD4 e da una alterazione dell’integrità della barriera intestinale. Questo imponente danno immunologico è poco recuperato dopo introduzione della cART. Per questo resta interessante lo studio della barriera intestinale in pz che hanno...
Following a solid organ transplant (SOT), immune responses of the recipient are profoundly altered; anti-rejection therapy causes a marked suppression of cell-mediated immune responses. We investigate T cell responses to a number of relevant and recall antigens of viral, bacterial or fungal origin in patients...
HIV infection facilitates the persistence of mucosal HPV and increases the risk of cytological abnormalities trough a mechanism still not fully understood. Recently, a role of altered microbiota has been described. Thus, we decided to explore the possible association(s) between HPV persistence, gut microbiota composition, microbial...
Background: CD8+CD28-CD127lowCD39+ T cells (CD8+Treg) are regulatory T lymphocytes, highly concentrated within tumor microenvironment, never analyzed in the circulation of HIV infected patients. Objectives: To analyze the frequency of CD8+ Treg in the circulation of HIV infected patients. Methods: The frequency of CD8+ Treg was analyzed and...
La variabilità dei sottotipi virali di HIV-1 nella popolazione con infezione da HIV in Italia sta subendo un rapido cambiamento a causa dell’aumento dei flussi migratori da aree geografiche in cui i sottotipi non-B sono dominanti. Le casistiche disponibili attestano la prevalenza dei sottotipi non-B...
INTRODUCTION AND OBJECTIVE HRQoL is a relevant feature in people living with HIV (PLWH)1. Frailty is associated to both medical and patient related outcomes2. We explore the association between Frailty and HRQoL in PLWH. MATERIAL AND METHODS Consecutive patients at the MHMC in 2015 with effective antiretroviral therapy...
BACKGROUND To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of...