INTRODUCTION AND AIMS In 2013, Mozambique adopted the Option B+ strategy proposed by WHO to improve the coverage of care of HIV infected children. A task-shifting (TS) from clinical officers to nurses was implemented to provide the continuum of care of newly HIV positive children <5...
PCSK9 is a soluble member of the mammalian proprotein convertase family of serine proteases (1), which is synthesized and secreted mainly by the liver (1). At transcriptional level PCSK9 synthesis is regulated by the Hepatocyte Nuclear Factor-1α (HNF1α), and by the Sterol Regulatory Element-Binding Protein-2...
Background: Anemia is frequent in HIV infection and is predictive of mortality, and antiretroviral therapy (cART) not always resolve it. We aimed to study iron homeostasis and inflammation evolution in patients with mild anemia in relation to cART. Methods: retrospective cohort study including HIV-infected patients with...
Detecting recent HIV infection is crucial to individualize a rapid initiation of treatment. Among the laboratory methods developed to discriminate recent infections, the Anti-HIV avidity index (AI) has been shown to accurately detect <6 months HIV infections. A longitudinal retrospective study was conducted on 82...
Vitamin D (VD) modulates the expression of genes, including those encoding drug metabolizers and transporters. Considering immunosuppressive drug levels vary during the year according to VD amount, VD-related markers could explain part of the variability in antiretrovirals (ARVs) exposure and therapy response/toxicity. Aims of this work are...
HIV establishes a latent infection at different degrees within naive (TN) or central (TCM) and effector memory (TEM) CD4+ T cell. Our main aim was to find which factors can influence intracellular viral reservoir in different CD4+ T-cell subsets, in HIV+ patients. We enrolled 32 HIV+...
Objectives To determine clinical and pharmacogenetic factors involved in the development of severe nevirapine (NVP) induced liver toxicity. Methods We retrospectively analyzed all HIV positive patients who were followed at the Infectious Disease Unit, DIBIC L.Sacco, University of Milan from January 2000 to December 2015. All patients treated...
Macrophages are present in all tissues and organs and represent primary targets of HIV-1 infection together with CD4+ T lymphocytes. Unlike CD4+ T cells, however, human macrophages are resistant to the cytopathic effects induced by virus infection both in vitro and in vivo. This observation,...
DUAL è uno studio pilota di fase III, randomizzato, controllato, open-label, condotto in pazienti HIV positivi trattati con PI/r e viremia soppressa. Lo scopo dello studio è comparare l’efficacia di una terapia antiretrovirale (TARV) duplice con darunavir/ritonavir (DRV/r) e rilpivirina (RPV) come strategia di switch....